Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul 28;23(28):5206-5215.
doi: 10.3748/wjg.v23.i28.5206.

Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps

Qin-Fen Chen  1 , Xiao-Dong Zhou  1 , Yang-Jie Sun  1 , Dan-Hong Fang  1 , Qian Zhao  1 , Jun-Hua Huang  1 , Yin Jin  1 , Jian-Sheng Wu  1
Affiliations

Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps

Qin-Fen Chen et al. World J Gastroenterol. .

Abstract

Aim: To investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and colorectal adenomatous and hyperplastic polyps.

Methods: A retrospective cross-sectional study was conducted on 3686 individuals undergoing health checkups (2430 males and 1256 females). All subjects underwent laboratory testing, abdominal ultrasonography, colonoscopy, and an interview to ascertain the baseline characteristics and general state of health. Multinomial logistic regression analysis was performed to examine the association between NAFLD and the prevalence of colorectal adenomatous and hyperplastic polyps. Furthermore, the relationship was analyzed in different sex groups. Subgroup analysis was performed based on number, size, and location of colorectal polyps.

Results: The prevalence of colorectal polyps was 38.8% in males (16.2% for adenomatous polyps and 9.8% for hyperplastic polyps) and 19.3% in females (8.4% for adenomatous polyps and 3.9% for hyperplastic polyps). When adjusting for confounding variables, NAFLD was significantly associated with the prevalence of adenomatous polyps (OR = 1.28, 95%CI: 1.05-1.51, P < 0.05) and hyperplastic polyps (OR = 1.35, 95%CI: 1.01-1.82, P < 0.05). However, upon analyzing adenomatous and hyperplastic polyps in different sex groups, the significant association remained in males (OR = 1.53, 95%CI: 1.18-2.00, P < 0.05; OR = 1.42, 95%CI: 1.04-1.95, P < 0.05) but not in females (OR = 0.44, 95%CI: 0.18-1.04, P > 0.05; OR = 1.18, 95%CI: 0.50-2.78, P > 0.05).

Conclusion: NAFLD is specifically associated with an increased risk of colorectal adenomatous and hyperplastic polyps in men. However, NAFLD may not be a significant factor in the prevalence of colorectal polyps in women.

Keywords: Adenomatous polyps; Health-check; Hyperplastic polyps; Non-alcoholic fatty liver disease.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: The authors declare that there is no conflict of interest with the paper presented.

Figures

Figure 1
Figure 1
Inclusion and exclusion of study participants.
See this image and copyright information in PMC

References

    1. Leslie A, Carey FA, Pratt NR, Steele RJ. The colorectal adenoma-carcinoma sequence. Br J Surg. 2002;89:845–860. - PubMed
    1. Jass JR. Hyperplastic polyps of the colorectum-innocent or guilty? Dis Colon Rectum. 2001;44:163–166. - PubMed
    1. Provenzale D, Garrett JW, Condon SE, Sandler RS. Risk for colon adenomas in patients with rectosigmoid hyperplastic polyps. Ann Intern Med. 1990;113:760–763. - PubMed
    1. Sciallero S, Costantini M, Bertinelli E, Castiglione G, Onofri P, Aste H, Casetti T, Mantellini P, Bucchi L, Parri R, et al. Distal hyperplastic polyps do not predict proximal adenomas: results from a multicentric study of colorectal adenomas. Gastrointest Endosc. 1997;46:124–130. - PubMed
    1. Croizet O, Moreau J, Arany Y, Delvaux M, Rumeau JL, Escourrou J. Follow-up of patients with hyperplastic polyps of the large bowel. Gastrointest Endosc. 1997;46:119–123. - PubMed

MeSH terms