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. 2017 Sep;9(9):782-787.
doi: 10.14740/jocmr3114w. Epub 2017 Jul 27.

Serum Betatrophin Levels and Clinical Features in Patients With Poorly Controlled Type 2 Diabetes

Kohzo Takebayashi  1 , Kenji Hara  1 , Tomoko Terasawa  1 , Rika Naruse  1 , Mariko Suetsugu  1 , Takafumi Tsuchiya  1 , Toshihiko Inukai  1
Affiliations

Serum Betatrophin Levels and Clinical Features in Patients With Poorly Controlled Type 2 Diabetes

Kohzo Takebayashi et al. J Clin Med Res. 2017 Sep.

Abstract

Background: Betatrophin is a hormone mainly secreted by the liver that influences lipid metabolisms. The main purposes of this study were to investigate the effect of canagliflozin (a sodium glucose transporter 2 inhibitor) on circulating betatrophin levels, and to investigate the correlation of various markers associated with glucose and lipid metabolisms with betatrophin in patients with poorly controlled type 2 diabetes.

Methods: Patients were randomly divided into a control group (n = 15) and a canagliflozin-treated group (n = 15). After hospitalization, the canagliflozin-treated group took 100 mg/day of canagliflozin for 3 days. Blood tests were performed at baseline and after 3 days of treatment.

Results: Canagliflozin treatment for 3 days did not significantly change fasting and postprandial serum betatrophin levels. On the other hand, betatrophin levels had a significant positive correlation with hemoglobin A1c, fasting plasma glucose, and high-density lipoprotein cholesterol levels at baseline.

Conclusions: The current study suggests that short-term treatment by canagliflozin does not influence circulating betatrophin levels, and that betatrophin is positively associated with markers of glycemic control and high-density lipoprotein cholesterol in patients with poorly controlled type 2 diabetes.

Keywords: Betatrophin; Canagliflozin; Type 2 diabetes.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Betatrophin levels in the control (a) and canagliflozin-treated groups (b).
Figure 2
Figure 2
The correlation of betatrophin with HbA1c (a) and HDL-C (b). HbA1c: hemoglobin A1c; HDL-C: high-density lipoprotein cholesterol.
See this image and copyright information in PMC

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