Insights into Asthma Therapies, Cardiovascular Effects, and Mechanisms from Recent Clinical Trials

Affiliations

Comment

Amy Attaway et al. Am J Respir Crit Care Med. 2017.

. 2017 Oct 1;196(7):920-922.

doi: 10.1164/rccm.201702-0428RR.

¹ Division of Pulmonary and Critical Care Medicine, University Hospitals Cleveland, Cleveland, Ohio.

No abstract available

Comment on

Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial.
Wenzel S, Castro M, Corren J, Maspero J, Wang L, Zhang B, Pirozzi G, Sutherland ER, Evans RR, Joish VN, Eckert L, Graham NM, Stahl N, Yancopoulos GD, Louis-Tisserand M, Teper A. Wenzel S, et al. Lancet. 2016 Jul 2;388(10039):31-44. doi: 10.1016/S0140-6736(16)30307-5. Epub 2016 Apr 27. Lancet. 2016. PMID: 27130691 Clinical Trial.
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, von Mutius E, Vercelli D, Ober C, Sperling AI. Stein MM, et al. N Engl J Med. 2016 Aug 4;375(5):411-421. doi: 10.1056/NEJMoa1508749. N Engl J Med. 2016. PMID: 27518660 Free PMC article.
Late-Onset Asthma Predicts Cardiovascular Disease Events: The Wisconsin Sleep Cohort.
Tattersall MC, Barnet JH, Korcarz CE, Hagen EW, Peppard PE, Stein JH. Tattersall MC, et al. J Am Heart Assoc. 2016 Aug 24;5(9):e003448. doi: 10.1161/JAHA.116.003448. J Am Heart Assoc. 2016. PMID: 27559071 Free PMC article.