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Editorial
. 2017 Dec 15;196(12):1502-1504.
doi: 10.1164/rccm.201708-1593ED.

Circulating Mitochondrial DNA as a Mechanism-based, Prognostic Biomarker for Idiopathic Pulmonary Fibrosis

Suzanne M Cloonan  1
Affiliations
Editorial

Circulating Mitochondrial DNA as a Mechanism-based, Prognostic Biomarker for Idiopathic Pulmonary Fibrosis

Suzanne M Cloonan. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Glycolytically reprogrammed idiopathic pulmonary fibrosis (IPF) fibroblasts drive a microenvironment that is enriched for mitochondrial DNA (mtDNA). Transforming growth factor (TGF)-β1 and direct contact with stiff surfaces (biomechanical model to mimic the IPF lung microenvironment) induce mtDNA release by normal human lung fibroblasts (NHLFs). Such a release of mtDNA is associated with a shift in metabolism of an NHLF from oxidative phosphorylation (mitochondrial dependent) to glycolysis. DAMP = damage-associated molecular pattern.
See this image and copyright information in PMC

Comment on

  • Extracellular Mitochondrial DNA Is Generated by Fibroblasts and Predicts Death in Idiopathic Pulmonary Fibrosis.
    Ryu C, Sun H, Gulati M, Herazo-Maya JD, Chen Y, Osafo-Addo A, Brandsdorfer C, Winkler J, Blaul C, Faunce J, Pan H, Woolard T, Tzouvelekis A, Antin-Ozerkis DE, Puchalski JT, Slade M, Gonzalez AL, Bogenhagen DF, Kirillov V, Feghali-Bostwick C, Gibson K, Lindell K, Herzog RI, Dela Cruz CS, Mehal W, Kaminski N, Herzog EL, Trujillo G. Ryu C, et al. Am J Respir Crit Care Med. 2017 Dec 15;196(12):1571-1581. doi: 10.1164/rccm.201612-2480OC. Am J Respir Crit Care Med. 2017. PMID: 28783377 Free PMC article.

References

    1. Patel AS, Song JW, Chu SG, Mizumura K, Osorio JC, Shi Y, El-Chemaly S, Lee CG, Rosas IO, Elias JA, et al. Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis. PLoS One. 2015;10:e0121246. - PMC - PubMed
    1. O’Dwyer DN, Ashley SL, Moore BB. Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2016;311:L590–L601. - PMC - PubMed
    1. Wuyts WA, Agostini C, Antoniou KM, Bouros D, Chambers RC, Cottin V, Egan JJ, Lambrecht BN, Lories R, Parfrey H, et al. The pathogenesis of pulmonary fibrosis: a moving target. Eur Respir J. 2013;41:1207–1218. - PubMed
    1. Ellson CD, Dunmore R, Hogaboam CM, Sleeman MA, Murray LA. Danger-associated molecular patterns and danger signals in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2014;51:163–168. - PubMed
    1. Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, et al. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med. 2013;10:e1001577. [Discussion, e1001577.] - PMC - PubMed