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Comment
. 2017 Aug 16:6:e30280.
doi: 10.7554/eLife.30280.

The benefits of data mining

Audrey Bone  1 , Keith Houck  1
Affiliations
Comment

The benefits of data mining

Audrey Bone et al. Elife. .

Abstract

Careful analysis of a database populated by physicians and patients sheds new light on the side effects of drugs.

Keywords: FAERS; adverse drug reactions; big data; data analysis; human; human biology; medicine.

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Conflict of interest statement

No competing interests declared.

Figures

Figure 1.
Figure 1.. Making the most of the FDA Adverse Event Reporting System (FAERS).
Patients, physicians, pharmacists and other health-care professionals input information about adverse drug reactions into the FAERS database. Maciejewski et al. have shown that it is possible to use data mining and statistical analysis to extract new insights about adverse drug reactions from the database: the first step is to deal with the noise and other problems associated with such crowd-sourced databases. The amount of reports in FAERS has grown rapidly over the past decade (top right; data from FDA).
See this image and copyright information in PMC

Comment on

References

    1. FDA 22 Case studies where phase 2 and phase 3 trials had divergent results. 2017 https://www.fda.gov/downloads/AboutFDA/ReportsManualsForms/Reports/UCM53...
    1. Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, Nakamura Y. When good drugs go bad. Nature. 2007;446:975–977. doi: 10.1038/446975a. - DOI - PubMed
    1. Kullak-Ublick GA, Andrade RJ, Merz M, End P, Benesic A, Gerbes AL, Aithal GP. Drug-induced liver injury: recent advances in diagnosis and risk assessment. Gut. 2017;66:1154–1164. doi: 10.1136/gutjnl-2016-313369. - DOI - PMC - PubMed
    1. Maciejewski M, Lounkine E, Whitebread S, Farmer P, DuMouchel W, Shoichet BK, Urban L. Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets. eLife. 2017;6:e25818. doi: 10.7554/eLife.25818. - DOI - PMC - PubMed
    1. Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL. Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000;102:2836–2841. doi: 10.1161/01.CIR.102.23.2836. - DOI - PubMed

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