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Review
. 2017 Nov 17;24(9):784-792.
doi: 10.2174/0929866524666170815161621.

Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma

Carlos Alberto de Carvalho Fraga  1 , Lucyana Conceicao Farias  2 , Kimberly Marie Jones  3 , Alfredo Mauricio Batista de Paula  2 , Andre Luiz Sena Guimaraes  2
Affiliations
Review

Angiotensin-Converting Enzymes (ACE and ACE2) as Potential Targets for Malignant Epithelial Neoplasia: Review and Bioinformatics Analyses Focused in Oral Squamous Cell Carcinoma

Carlos Alberto de Carvalho Fraga et al. Protein Pept Lett. .

Abstract

Introduction: The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer.

Objective: This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical targets for Malignant Epithelial Neoplasia, specifically for Oral Squamous Cell Carcinoma (OSCC).

Conclusion: The literature review and Bioinformatics analyses showed that ACE and ACE2 are interesting targets for OSCC treatment. Studies involving RAS and OSCC should be encouraged for experimental validation.

Keywords: ACE; Ang 1-7; Angiogenesis; Head and neck cancer; angiotensin-converting enzyme.; obesity.

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