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Comment
. 2018 Aug;67(8):1555-1557.
doi: 10.1136/gutjnl-2017-314759. Epub 2017 Aug 16.

Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression

Bruce R Stevens  1   2 , Ruby Goel  1 , Kim Seungbum  1 , Elaine M Richards  1 , Richard C Holbert  2 , Carl J Pepine  3 , Mohan K Raizada  1
Affiliations
Comment

Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression

Bruce R Stevens et al. Gut. 2018 Aug.
No abstract available

Keywords: bacterial enterotoxin; brain/gut interactions; enteric bacterial microflora; intestinal barrier function; psychosomatic medicine.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
PICRUSt metagenome KEGG orthologue gene distribution in microbiomes of depressive disorder or an anxiety disorder (DEP/ANX) versus control subjects (see online supplementary material). LDA, linear discriminate analysis; TCA, tricarboxylic acid; tRNA, transfer RNA.
Figure 2
Figure 2
Plasma LPS endotoxin, zonulin and fatty acid-binding protein-2 (FABP2) blood markers of gut dysbiosis and gut permeability pathophysiological epithelium integrity. Analysis of variance yielded significant mean differences (p<0.05) (see online supplementary material).
See this image and copyright information in PMC

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