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. 2017 Jul;9(Suppl 8):S861-S867.
doi: 10.21037/jtd.2017.06.61.

Predictive factors for post-operative respiratory infections after esophagectomy for esophageal cancer: outcome of randomized trial

Surya Say Biere  1 , Mark I van Berge Henegouwen  2 , Luigi Bonavina  3 , Camiel Rosman  4 , Josep Roig Garcia  5 , Suzanne S Gisbertz  5 , Donald L van der Peet  1 , Miguel A Cuesta  1
Affiliations

Predictive factors for post-operative respiratory infections after esophagectomy for esophageal cancer: outcome of randomized trial

Surya Say Biere et al. J Thorac Dis. 2017 Jul.

Abstract

Background: The first and only randomized trial comparing open esophagectomy (OE) with minimally invasive esophagectomy (MIE) showed a significant lower incidence of post-operative respiratory infections in the patients who underwent MIE. In order to identify which specific factors are related to a better respiratory outcome in this trial an additional analysis was performed.

Methods: This was a prospective, multicenter, randomized controlled trial. Eligible patients, with a resectable intrathoracic esophageal carcinoma, including the gastro-esophageal (GE) junction tumors and Eastern Cooperative Oncology Group ≤2, were randomized to either MIE or OE. Respiratory infection investigated was defined as a clinical manifestation of (broncho-) pneumonia confirmed by thorax X-ray and/ or Computed Tomography scan and a positive sputum culture. A logistic regression model was used.

Results: From 2009 to 2011, 115 patients were randomized in 5 centers. Eight patients developed metastasis during neoadjuvant therapy or had an irresectable tumor and were therefore excluded from the analysis. Fifty-two OE patients were comparable to 55 MIE patients with regard to baseline characteristics. In-hospital mortality was not significantly different [2% (open group) and 4% (MIE group)]. A body mass index (BMI) ≥26 and OE were associated with a roughly threefold risk of developing a respiratory infection.

Conclusions: Overweight patients and OE are independently associated with a significant higher incidence of post-operative respiratory infections, i.e., pneumonia.

Keywords: Minimally invasive; esophagectomy; obesity; open esophagectomy (OE); pneumonia; respiratory infections.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Enrollment and outcomes. MIE, minimally invasive esophagectomy; THE, transhiatal esophagectomy.
See this image and copyright information in PMC

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