[Differentially expressed genes between the human mandible- and ilium- derived mesenchymal cells]

Abstract

Purpose: To explore the differentially expressed genes between human mandible- and ilium- derived mesenchymal cells.

Methods: Differentially expressed genes between the human mandible- and ilium- derived mesenchymal cells were obtained from the GEO database based on the analysis of GEO2R software, then the relationship among these genes were analysed using DAVID and Gene MANIA on-line database.

Results: Two hundred and ninety three differentially expressed genes between the human mandible and iliac derived mesenchymal cells were obtained, and most of them were homeobox genes that related to bone development. These genes could also be enriched into different subgroups based on the analysis of DAVID database, such as "skeletal system development", "forebrain development", "limb development" and "WNT signaling pathway". After the analysis from Gene MANIA database, the molecular networks of MSX1, MSX2, HAND2, SIX1, PITX2, OSR2, PAX3 and PRRX1 were built to show that these eight genes exhibited interactions, including co-expression, co-localization, genetic interactions.

Conclusions: There are different gene regulating mechanisms between the human mandible- and ilium- derived mesenchymal cells. It implies that genetic modification may be applied to get iliac derived mesenchymal cells to be more suitable for tissue-engineered repair of jaw.