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Review
. 2018 Mar-Apr;20(2):138-144.
doi: 10.4103/aja.aja_25_17.

Testosterone treatment and cardiovascular events in prescription database studies

Molly M Shores  1
Affiliations
Review

Testosterone treatment and cardiovascular events in prescription database studies

Molly M Shores. Asian J Androl. 2018 Mar-Apr.

Abstract

Over the past decade, there has been a substantial increase in the number of men who are treated with testosterone. Despite this increase in the use of testosterone, the risks of adverse cardiovascular events are unclear as meta-analyses have reported conflicting findings and no clinical studies have been large enough or long enough to adequately assess for cardiovascular risks. The goal of this paper is to review large prescription database studies of testosterone treatment and adverse cardiovascular events and mortality with the aim of providing some guidance for clinicians and researchers in this controversial area.

Keywords: cardiovascular diseases; cohort studies; myocardial infarction; stroke; testosterone/adverse effects; thrombosis.

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References

    1. Shabsigh R, Arver S, Channer KS, Eardley I, Fabbri A, et al. The triad of erectile dysfunction, hypogonadism and the metabolic syndrome. Int J Clin Pract. 2008;62:791–8. - PMC - PubMed
    1. Yeap BB, Chubb SA, Hyde Z, Jamrozik K, Hankey GJ, et al. Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study. Eur J Endocrinol. 2009;161:591–8. - PubMed
    1. Isidori AM, Giannetta E, Pozza C, Bonifacio V, Isidori A. Androgens, cardiovascular disease and osteoporosis. J Endocrinol Invest. 2005;28:73–9. - PubMed
    1. Shores MM, Matsumoto AM, Sloan KL, Kivlahan DR. Low serum testosterone and mortality in male veterans. Arch Intern Med. 2006;166:1660–5. - PubMed
    1. Laughlin GA, Barrett-Connor E, Bergstrom J. Low serum testosterone and mortality in older men. J Clin Endocrinol Metab. 2008;93:68–75. - PMC - PubMed