Amniotic fluid embolism mortality rate

Abstract

Aim: The objective of this study was to determine the mortality rate of amniotic fluid embolism (AFE) using population-based studies and case series.

Methods: A literature search was conducted using the two key words: 'amniotic fluid embolism (AFE)' AND 'mortality rate'. Thirteen population-based studies were evaluated, as well as 36 case series including at least two patients.

Results: The mortality rate from population-based studies varied from 11% to 44%. When nine population-based studies with over 17 000 000 live births were aggregated, the maternal mortality rate was 20.4%. In contrast, the mortality rate of AFE in case series varies from 0% to 100% with numerous rates in between.

Conclusion: The AFE mortality rate in population-based studies varied from 11% to 44% with the best available evidence supporting an overall mortality rate of 20.4%. Data from case series should no longer be used as a basis for describing the lethality of AFE.

Keywords: amniotic fluid embolism; case series; maternal mortality; maternal mortality rate; population-based study.