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. 2017 Dec;33(12):918-921.
doi: 10.1016/j.pt.2017.07.007. Epub 2017 Aug 14.

Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Moses Egesa  1 , Karl F Hoffmann  2 , Cornelis H Hokke  3 , Maria Yazdanbakhsh  3 , Stephen Cose  4
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Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Moses Egesa et al. Trends Parasitol. 2017 Dec.

Abstract

There is currently no vaccine against schistosomiasis. With few Schistosoma vaccine candidates in clinical trials, unexplored antigens from the vulnerable schistosomulum should be considered as possible vaccine candidates. In addition, we suggest developing synthetic vesicles as a new delivery vehicle and adjuvant for immunoprophylactic schistosomula vaccine candidates.

Keywords: Schistosoma; adjuvant; delivery; schistosomula; synthetic vesicles; vaccine candidates.

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