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Case Reports
. 2017 Oct 7;79(10):1694-1697.
doi: 10.1292/jvms.17-0271. Epub 2017 Aug 17.

Lissencephaly in a Pekingese

Genya Shimbo  1 , Michihito Tagawa  1 , Eiji Oohashi  2 , Masashi Yanagawa  3 , Kazuro Miyahara  1
Affiliations
Case Reports

Lissencephaly in a Pekingese

Genya Shimbo et al. J Vet Med Sci. .

Abstract

A 1-year-old neutered male Pekingese was presented for evaluation and further treatment of cluster seizures. The dog had behavioral abnormalities, and a prosencephalic lesion was suspected following neurological examination. The dog showed signs of learning difficulty. Magnetic resonance imaging of the brain revealed a remarkably smooth cerebral cortex with a reduced number of gyri, as well as a cystic lesion associated with the quadrigeminal cistern. A diagnosis of lissencephaly, concurrent with a quadrigeminal cisternal cyst, was made. High-dose and multiple anticonvulsants were necessary to control the seizures. This is the first report of lissencephaly in a Pekingese.

Keywords: Pekingese; lissencephaly; magnetic resonance imaging.

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Figures

Fig. 1.
Fig. 1.
Transverse T2WI at the level of the frontal lobes (A), the mid-diencephalon (B), and the midbrain (C) and dorsal T2WI at the level of corpus callosum (D) showing a remarkably smooth cerebral cortex. A small number of shallow sulci were present in the frontal (arrows) and temporal lobes (arrowheads), but absent in the occipital lobes.
Fig. 2.
Fig. 2.
Transverse T2WI at the level of the rostral part of the midbrain (A), mid-sagittal brain T2WI (B) and T1WI (C). A cystic lesion at the quadrigeminal cistern in association with the 3rd ventricle was identified.
See this image and copyright information in PMC

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