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Editorial
. 2017 Oct 2;16(19):1733-1734.
doi: 10.1080/15384101.2017.1360654. Epub 2017 Aug 18.

It takes energy to resist force

Jennifer L Bays  1 , Kris A DeMali  1
Affiliations
Editorial

It takes energy to resist force

Jennifer L Bays et al. Cell Cycle. .
No abstract available

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Figures

Figure 1.
Figure 1.
The signal transduction cascade initiated by E-cadherin in response to force. Active AMPK stimulates increased contractility through Abl tyrosine kinase mediated phosphorylation of Y822 vinculin and the subsequent activation of RhoA and myosin II. Active AMPK also signals for an increase in glucose uptake. The glucose is converted into ATP and provides the energy necessary to support the cytoskeletal rearrangements necessary for cell stiffening.
See this image and copyright information in PMC

Comment on

References

    1. Bays JL, Campbell HK, Heidema C, Sebbagh M, DeMali KA. Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK. Nature cell biology. 2017;19:724-31. doi: 10.1038/ncb3537. PMID:28553939. - DOI - PMC - PubMed
    1. Sebbagh M, Santoni MJ, Hall B, Borg JP, Schwartz MA. Regulation of LKB1/STRAD localization and function by E-cadherin. Curr Biol: CB. 2009;19:37-42. doi: 10.1016/j.cub.2008.11.033. PMID:19110428. - DOI - PMC - PubMed
    1. Bays JL, Peng X, Tolbert CE, Guilluy C, Angell AE, Pan Y, Superfine R, Burridge K, DeMali KA. Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions. J Cell Biol. 2014;205:251-63. doi: 10.1083/jcb.201309092. PMID:24751539. - DOI - PMC - PubMed
    1. Daniel JL, Molish IR, Robkin L, Holmsen H. Nucleotide exchange between cytosolic ATP and F-actin-bound ADP may be a major energy-utilizing process in unstimulated platelets. European journal of biochemistry / FEBS. 1986;156:677-84. doi: 10.1111/j.1432-1033.1986.tb09631.x - DOI - PubMed
    1. Bernstein BW, Bamburg JR. Actin-ATP hydrolysis is a major energy drain for neurons. J Neurosci. 2003;23:1-6. PMID:12514193. - PMC - PubMed

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