Understanding Hepatitis C Virus Drug Resistance: Clinical Implications for Current and Future Regimens
- PMID: 28820725
- PMCID: PMC5935211
Understanding Hepatitis C Virus Drug Resistance: Clinical Implications for Current and Future Regimens
Abstract
Viral resistance to direct-acting antiviral drugs may impact their effectiveness during treatment of hepatitis C virus (HCV) infection. Most data on HCV drug resistance concern genotypes 1 and 3. The clinical impact of resistance to HCV nonstructural protein 5A (NS5A) inhibitors and a practical approach to indications and methods for resistance testing are discussed.
References
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- Wyles DL, Gutierrez JA. Importance of HCV genotype 1 subtypes for drug resistance and response to therapy. J Viral Hepat. 2014;21(4):229–240. - PubMed
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- Wyles D, Dvory-Sobol H, Svarovskaia ES, et al. Post-treatment resistance analysis of hepatitis C virus from phase II and III clinical trials of ledipasvir/sofosbuvir. J Hepatol. 2017;66(4):703–710. - PubMed
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