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. 2017 Jun;13(2):113-118.

The Impact of Biophysical Properties of Erythrocytes on their Aggregation

Mohamed A Elblbesy  1   2 , Maisa E Moustafa  1
Affiliations

The Impact of Biophysical Properties of Erythrocytes on their Aggregation

Mohamed A Elblbesy et al. Int J Biomed Sci. 2017 Jun.

Abstract

Erythrocytes aggregation takes places under low shear conditions or at stasis. All suggested mechanisms of erythrocytes aggregation indicated the importance role of fibrinogen and other blood proteins in enhanced erythrocyte aggregation. Recently a special attention is given to the cellular factors that may effect on erythrocytes aggregation. The present study inferred the effect of the cellular properties of erythrocytes on their aggregation. In the present study, aggregation index was calculated by a simple microscopic method. Correlations between erythrocytes aggregation index and mean cell volume, osmotic fragility, electrophoretic mobility, and magnetophoretic mobility were studied. The findings of this study indicated that the aggregation index is significatly correlated to mean cell volume, magnetophoretic mobility, osmotic fragility and electrophoretic mobility. Thus, It is concluded that cellular factors should be taken into consideration when studying the mechanism of erythrocytes aggregation.

Keywords: Aggregation; Erythrocytes; Mean cell volume; electrophoretic mobility; magnetophoretic mobility; osmotic fragility.

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Figures

Figure 1
Figure 1
Correlation between aggregation index and mean cell volume.
Figure 2
Figure 2
Correlation between aggregation index (AI) and osmotic fragility index.
Figure 3
Figure 3
Correlation between aggregation index (AI) and electrophoretic mobility (EPM).
Figure 4
Figure 4
Correlation between aggregation index (AI) and magnetophoretic mobility (MPM).
See this image and copyright information in PMC

References

    1. Armstrong JK, et al. The Hydrodynamic Radii of Macromolecules and Their Effect on Red Blood Cell Aggregation. Biophysical Journal. 2004;87(6):4259–4270. - PMC - PubMed
    1. Weng X, et al. Influence of acute-phase proteins on erythrocyte aggregation. Am. J. Physiol. 1996;271(6 Pt 2):2346–2352. - PubMed
    1. Chien S, Jan K. Ultrastructural basis of the mechanism of rouleaux formation. Microvasc Res. 1973;5(2):155–166. - PubMed
    1. Armstrong JK, Meiselman HJ, Fisher TC. Evidence against macromolecular "bridging" as the mechanism of red blood cell aggregation induced by nonionic polymers. Biorheology. 1999;36(5-6):433–437. - PubMed
    1. Chien S. Biophysical behavior of red cells in suspensions. The red blood cell. 1975;2(4):1031–1133.

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