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Comment
. 2016 Aug;5(Suppl 2):S221-S225.
doi: 10.21037/tcr.2016.08.15.

Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy

Fabiana Perna  1 , Michel Sadelain  1
Affiliations
Comment

Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy

Fabiana Perna et al. Transl Cancer Res. 2016 Aug.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Comment on

References

    1. Gardner R, Wu D, Cherian S, et al. Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy. Blood. 2016;127:2406–10. - PMC - PubMed
    1. Sadelain M. CAR therapy: the CD19 paradigm. J Clin Invest. 2015;125:3392–400. - PMC - PubMed
    1. Couzin-Frankel J. Breakthrough of the year 2013. Cancer immunotherapy Science. 2013;342:1432–3. - PubMed
    1. Zhou G, Levitsky H. Towards curative cancer immunotherapy: overcoming posttherapy tumor escape. Clin Dev Immunol. 2012;2012:124187. - PMC - PubMed
    1. van der Stegen SJ, Hamieh M, Sadelain M. The pharmacology of second-generation chimeric antigen receptors. Nat Rev Drug Discov. 2015;14:499–509. - PMC - PubMed