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Meta-Analysis
. 2017 Aug 21;18(1):89.
doi: 10.1186/s12881-017-0452-1.

Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis

Ai Ling Liu  1   2   3 , Hui Jun Xie  1 , Hong Yan Xie  1 , Jun Liu  1 , Jie Yin  1 , Jin Song Hu  1 , Cui Ying Peng  4   5   6
Affiliations
Meta-Analysis

Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis

Ai Ling Liu et al. BMC Med Genet. .

Abstract

Background: Up to now, numerous case-control studies have reported the associations between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome (PCOS), however, without a consistent result. Hence we performed current systematic review and meta-analysis to clarify the controversial results.

Methods: Case-control studies reporting the relationship of rs9939609 A/T polymorphism and PCOS published before April 2015 were searched in Pubmed database without language restriction. Data was analyzed by Review Manager 5.2.

Results: A total of five studies involving 5010 PCOS patients and 5300 controls were included for further meta-analysis. The results of meta-analysis showed that the FTO gene rs9939609 A/T polymorphism was significantly different between PCOS group and control group in different gene models (For AA + AT vs. TT: OR = 1.41, 95% CI = 1.28-1.55, P < 0.00001. For AA vs. AT + TT: OR = 1.54, 95% CI = 1.25-1.89, P < 0.0001. For AA vs. TT: OR = 1.74, 95% CI = 1.38-2.18, P < 0.00001. For A vs. T: OR = 1.36, 95% CI = 1.25-1.47, P < 0.00001, respectively) suggesting that A allele was a risk factor for PCOS susceptibility. Furthermore, subgroup analysis in Asian and Caucasian ethnicities also found significant association between rs9939609 A/T polymorphism and PCOS (In Asian subgroup: OR = 1.43, 95% CI = 1.29-1.59, P < 0.0001. In Caucasian subgroup: OR = 1.33, 95% CI = 1.08-1.64, P = 0.008) CONCLUSION: This meta-analysis suggests that rs9939609 A/T polymorphism of FTO gene is associated with PCOS risk, and that A allele is a risk factor for PCOS susceptibility simultaneously.

Keywords: FTO; Meta-analysis; Polycystic ovary syndrome; Polymorphism.

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Conflict of interest statement

Ethics approval and consent to participate

The manuscript has been read and approved by all the authors. The research adhered to the tenets of The Declaration of Helsinki. The Ethics Committee of Nanhua-Xinghui Hospital approved the protocol. Written informed consent was obtained from all participants among these cited references (12–16).

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
The flow chart of study selection
Fig. 2
Fig. 2
The association between FTO rs9939609 A/T polymorphism and risk of PCOS. (a) AA + AT vs. TT in overall analysis, (b) AA vs. AT + TT in overall analysis, (c) AA vs. TT in overall analysis, (d) A vs. T in overall analysis. For each study, the solid squares represent the ORs from the individual studies, horizontal lines represent corresponding 95% CIs. The pooled ORs and 95% CIs are shown by the shaded diamonds
Fig. 3
Fig. 3
The association between FTO rs9939609 A/T polymorphism and risk of PCOS in subgroup model. The analysis was stratified by race. AA + AT vs. TT in subgroup (Caucasian and Asian) analysis of HWE > 0.05. The solid squares represent the ORs from the individual studies, horizontal lines represent corresponding 95% CIs. The pooled ORs and 95% CIs are presented as diamonds
Fig. 4
Fig. 4
Funnel plot of publication bias in selection of studies on the FTO rs9939609 A/T polymorphism. Publication bias was assessed under dominant model (AA + AT vs. TT). SE represents standard error; OR represents odds ratio
See this image and copyright information in PMC

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