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Comment
. 2017 Sep 15;36(18):2667-2669.
doi: 10.15252/embj.201797773. Epub 2017 Aug 21.

Stem cells make leukemia grow again

Carsten Bahr  1   2 , Nádia C Correia  1   2 , Andreas Trumpp  1   2   3
Affiliations
Comment

Stem cells make leukemia grow again

Carsten Bahr et al. EMBO J. .

Abstract

Leukemic stem cells were hypothesized to play a critical role in acute myeloid leukemia relapse, but data to support this were lacking. In a recent study elegantly combining sequencing with functional xenograft assays, Shlush et al (2017) identified two distinct origins of leukemic relapse. They provided direct experimental evidence linking relapse to cancer stem cell clones already present before therapeutic intervention.

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Figures

Figure 1
Figure 1. Relapse‐relevant leukemic stem cells (LSCs) are already present at diagnosis and arise from two distinct origins
Top: Relapse of primitive origin (ROP) arises from rare LSCs with a functional and cellular phenotype of hematopoietic stem and progenitor cell (HSPC). Bottom: Relapse from LSCs of committed origin (ROC) arises from larger clones of LSCs with a myeloid phenotype, which however possess a stemness expression profile.
See this image and copyright information in PMC

Comment on

  • Tracing the origins of relapse in acute myeloid leukaemia to stem cells.
    Shlush LI, Mitchell A, Heisler L, Abelson S, Ng SWK, Trotman-Grant A, Medeiros JJF, Rao-Bhatia A, Jaciw-Zurakowsky I, Marke R, McLeod JL, Doedens M, Bader G, Voisin V, Xu C, McPherson JD, Hudson TJ, Wang JCY, Minden MD, Dick JE. Shlush LI, et al. Nature. 2017 Jul 6;547(7661):104-108. doi: 10.1038/nature22993. Epub 2017 Jun 28. Nature. 2017. PMID: 28658204

References

    1. Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3: 730–737 - PubMed
    1. Cabezas‐Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor‐Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schonberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D et al (2017) Vitamin A‐Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cell 169: 807–823 e819 - PubMed
    1. Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, Dooling DJ, Fulton RS, Fulton LL, Chen K, Schmidt H et al (2012) Clonal evolution in relapsed acute myeloid leukaemia revealed by whole‐genome sequencing. Nature 481: 506–510 - PMC - PubMed
    1. Kreso A, Dick JE (2014) Evolution of the cancer stem cell model. Cell Stem Cell 14: 275–291 - PubMed
    1. Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Gorlich D, Buchner T, Hiddemann W, Berdel WE, Wormann B, Cheok M et al (2016) A 17‐gene stemness score for rapid determination of risk in acute leukaemia. Nature 540: 433–437 - PubMed

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