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. 2017:1660:433-440.
doi: 10.1007/978-1-4939-7253-1_35.

Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles

Jing Liu  1   2   3 , Jingwei Ma  4 , Ke Tang  3 , Bo Huang  5   6
Affiliations

Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles

Jing Liu et al. Methods Mol Biol. 2017.

Abstract

Extracellular vesicles (EVs) are nanosized membrane vesicles, released by many cell types, which are an ideal drug-delivery system for antitumor therapy. Exosomes, microparticles (MP), and apoptotic bodies are the three main types of EVs. MPs are EVs with size ranges between 100 and 1000 nm. Tumor cell-derived EVs (T-EVs) can serve as a safe and efficient vehicle to specific deliver chemotherapeutic drugs or oncolytic adenoviruses for tumor treatment. In this section, we describe how to prepare EVs for therapeutic use.

Keywords: Chemotherapeutic drugs; Dendritic cells; Drug delivery; Extracellular vesicles; Oncolytic adenoviruses; Tumor antigens; Tumor microparticles; Tumor vaccines.

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