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Case Reports
. 2017 Aug 22;18(8):1818.
doi: 10.3390/ijms18081818.

Peritoneal Mesothelioma with Residential Asbestos Exposure. Report of a Case with Long Survival (Seventeen Years) Analyzed by Cgh-Array

Gabriella Serio  1 , Federica Pezzuto  2 , Andrea Marzullo  3 , Anna Scattone  4 , Domenica Cavone  5 , Alessandra Punzi  6 , Francesco Fortarezza  7 , Mattia Gentile  8 , Antonia Lucia Buonadonna  9 , Mattia Barbareschi  10 , Luigi Vimercati  11
Affiliations
Case Reports

Peritoneal Mesothelioma with Residential Asbestos Exposure. Report of a Case with Long Survival (Seventeen Years) Analyzed by Cgh-Array

Gabriella Serio et al. Int J Mol Sci. .

Abstract

Malignant mesothelioma is a rare and aggressive tumor with limited therapeutic options. We report a case of a malignant peritoneal mesothelioma (MPM) epithelioid type, with environmental asbestos exposure, in a 36-year-old man, with a long survival (17 years). The patient received standard treatment which included cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).

Methods and results: Molecular analysis with comparative genomic hybridization (CGH)-array was performed on paraffin-embedded tumoral samples. Multiple chromosomal imbalances were detected. The gains were prevalent. Losses at 1q21, 2q11.1→q13, 8p23.1, 9p12→p11, 9q21.33→q33.1, 9q12→q21.33, and 17p12→p11.2 are observed. Chromosome band 3p21 (BAP1), 9p21 (CDKN2A) and 22q12 (NF2) are not affected. Conclusions: the defects observed in this case are uncommon in malignant peritoneal mesothelioma. Some chromosomal aberrations that appear to be random here, might actually be relevant events explaining the response to therapy, the long survival and, finally, may be considered useful prognostic factors in peritoneal malignant mesothelioma (PMM).

Keywords: asbestos; mesothelioma; molecular-array; peritoneum.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Malignant peritoneal mesothelioma: histology, immunohistochemical (IHC) and comparative genomic hybridization (CGH)-array results.
See this image and copyright information in PMC

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