Protein Clustering Shapes Polarity Protein Gradients
- PMID: 28829939
- DOI: 10.1016/j.devcel.2017.08.006
Protein Clustering Shapes Polarity Protein Gradients
Abstract
In this issue of Developmental Cell, Dickinson et al. (2017) and Rodriguez et al. (2017), along with Wang et al. (2017) in Nature Cell Biology, show how PAR protein oligomerization can dynamically couple protein diffusion and transport by cortical flow to control kinase activity gradients and polarity in the C. elegans zygote.
Copyright © 2017. Published by Elsevier Inc.
Comment on
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aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity.Dev Cell. 2017 Aug 21;42(4):400-415.e9. doi: 10.1016/j.devcel.2017.07.007. Epub 2017 Aug 3. Dev Cell. 2017. PMID: 28781174 Free PMC article.
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A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization.Dev Cell. 2017 Aug 21;42(4):416-434.e11. doi: 10.1016/j.devcel.2017.07.024. Dev Cell. 2017. PMID: 28829947 Free PMC article.
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