Patchy Growth Control
- PMID: 28829940
- DOI: 10.1016/j.devcel.2017.08.007
Patchy Growth Control
Abstract
TORC1 is arguably the best-studied regulator of cellular growth in eukaryotes. However, its activity has not been assessed in vivo in developing multicellular organisms. Two studies in this issue of Developmental Cell (Kim et al., 2017; Romero-Pozuelo et al., 2017) surprisingly reveal a patchy, cell-cycle-controlled pattern of TORC1 activation in Drosophila imaginal discs.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye.Dev Cell. 2017 Aug 21;42(4):363-375.e4. doi: 10.1016/j.devcel.2017.07.020. Dev Cell. 2017. PMID: 28829944
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CycD/Cdk4 and Discontinuities in Dpp Signaling Activate TORC1 in the Drosophila Wing Disc.Dev Cell. 2017 Aug 21;42(4):376-387.e5. doi: 10.1016/j.devcel.2017.07.019. Dev Cell. 2017. PMID: 28829945
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