Humanized mice: models for evaluating NeuroHIV and cure strategies

Abstract

While the human immunodeficiency virus (HIV) epidemic was initially characterized by a high prevalence of severe and widespread neurological pathologies, the development of better treatments to suppress viremia over years and even decades has mitigated many of the severe neurological pathologies previously observed. Despite effective treatment, mild neurocognitive impairment and premature cognitive aging are observed in HIV-infected individuals, suggesting a changing but ongoing role of HIV infection in the central nervous system (CNS). Although current therapies are effective in suppressing viremia, they are not curative and patients must remain on life-long treatment or risk recrudescence of virus. Important for the development and evaluation of a cure for HIV will be animal models that recapitulate critical aspects of infection in vivo. In the following, we seek to summarize some of the recent developments in humanized mouse models and their usefulness in modeling HIV infection of the CNS and HIV cure strategies.

Keywords: Antiretroviral therapy (ART); CNS; HIV/AIDS; Humanized mice; NeuroHIV.

Figure 1:. Schematic of humanized mouse models for evaluating NeuroHIV infection and/or cure strategies.

The name of each model is followed by the human cells/tissues and immunodeficient mouse strains used in the generation of each type of humanized mouse. Brief description of advantages and disadvantages of each model are listed.