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. 1987 Jun;61(6):2059-62.
doi: 10.1128/JVI.61.6.2059-2062.1987.

Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D

M Ono, M Kawakami, H Ushikubo

Stimulation of expression of the human endogenous retrovirus genome by female steroid hormones in human breast cancer cell line T47D

M Ono et al. J Virol. 1987 Jun.

Abstract

Expression of the human endogenous retrovirus genome HERV-K, homologous to mouse mammary tumor virus, was investigated in cultured human tumor cells. In several cell lines, the HERV-K genome was expressed as an 8.8-kilobase poly(A)+ RNA which appeared to be a full-size transcript of this genome. In the human breast cancer cell line T47D, stimulation of HERV-K genome expression by progesterone was observed after estradiol treatment.

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