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. 2018 Apr;79(4):2190-2197.
doi: 10.1002/mrm.26886. Epub 2017 Aug 22.

Fast 3D magnetic resonance fingerprinting for a whole-brain coverage

Dan Ma  1 , Yun Jiang  1 , Yong Chen  1 , Debra McGivney  1 , Bhairav Mehta  1 , Vikas Gulani  1 , Mark Griswold  1
Affiliations

Fast 3D magnetic resonance fingerprinting for a whole-brain coverage

Dan Ma et al. Magn Reson Med. 2018 Apr.

Abstract

Purpose: The purpose of this study was to accelerate the acquisition and reconstruction time of 3D magnetic resonance fingerprinting scans.

Methods: A 3D magnetic resonance fingerprinting scan was accelerated by using a single-shot spiral trajectory with an undersampling factor of 48 in the x-y plane, and an interleaved sampling pattern with an undersampling factor of 3 through plane. Further acceleration came from reducing the waiting time between neighboring partitions. The reconstruction time was accelerated by applying singular value decomposition compression in k-space. Finally, a 3D premeasured B1 map was used to correct for the B1 inhomogeneity.

Results: The T1 and T2 values of the International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology MRI phantom showed a good agreement with the standard values, with an average concordance correlation coefficient of 0.99, and coefficient of variation of 7% in the repeatability scans. The results from in vivo scans also showed high image quality in both transverse and coronal views.

Conclusions: This study applied a fast acquisition scheme for a fully quantitative 3D magnetic resonance fingerprinting scan with a total acceleration factor of 144 as compared with the Nyquist rate, such that 3D T1 , T2 , and proton density maps can be acquired with whole-brain coverage at clinical resolution in less than 5 min. Magn Reson Med 79:2190-2197, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

Keywords: 3D; MR fingerprinting; T1; T2; relaxometry.

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Figures

Figure 1
Figure 1
Undersampling scheme (a), flip angle pattern and TR pattern (b) of the 3D MRF scan. In (a), the sampling scheme of a 3D MRF scan with nine partitions is illustrated. The acquisition starts with the time domain first. Along the time points, the rotational angles of the spiral trajectories are changed with a step of 7.5 degrees. With an acceleration factor of three, nine partitions are divided into three groups or repetitions. The colored kz lines are the ones that are acquired in the accelerated scan while the gray kz lines are the ones that are skipped.
Figure 2
Figure 2
The accuracy and repeatability of the qMRI phantom scan. (a, b) T1 values and T2 values from 14 spheres from the ISMRM/NIST phantom are compared to the values from the spin echo (SE) measurement. (c, d) The same results but with a reduced T1 range between 181 to 2038 ms and a reduced T2 range between 26 to 143 ms. The blue line and red line in each plot are the linear regression results before and after B1 correction, respectively.
Figure 3
Figure 3
B1, T1 and T2 maps from a 3D in vivo scan in axial view.
Figure 4
Figure 4
3D T1 (ms) and T2 (ms) maps from an in vivo scan in Coronal view.
See this image and copyright information in PMC

References

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