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Review
. 2018 Jan;65(1).
doi: 10.1002/pbc.26718. Epub 2017 Aug 22.

Consequences of diagnosing a tumor predisposition syndrome in children with cancer: A literature review

Floor A M Postema  1 , Saskia M J Hopman  1   2 , Raoul C Hennekam  3 , Johannes H M Merks  1
Affiliations
Review

Consequences of diagnosing a tumor predisposition syndrome in children with cancer: A literature review

Floor A M Postema et al. Pediatr Blood Cancer. 2018 Jan.

Abstract

Up to 8.5% of children with cancer have a genetic cause for their cancer: a tumor predisposition syndrome (TPS). Diagnosing a TPS is of great importance, as it may have major consequences for clinical care. Patients with TPSs require specific monitoring and management. We present an overview of the cancer-related and noncancer-related consequences for the 36 most common TPSs.

Keywords: cancer; consequences; genetic predisposition to disease; pediatrics.

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