B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutation

Affiliations

¹ Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
² Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
³ Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands.

^# Contributed equally.

Rochelle D Vergroesen et al. Ann Rheum Dis. 2018 Jun.

. 2018 Jun;77(6):956-958.

doi: 10.1136/annrheumdis-2017-212052. Epub 2017 Aug 23.

¹ Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
² Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
³ Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands.

^# Contributed equally.

No abstract available

Keywords: B cells; ant-ccp; autoantibodies; autoimmunity; rheumatoid arthritis.

Conflict of interest statement

Competing interests: None declared.

Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases.
Visser A, Hamza N, Kroese FGM, Bos NA. Visser A, et al. Ann Rheum Dis. 2018 Oct;77(10):e69. doi: 10.1136/annrheumdis-2017-212568. Epub 2017 Nov 4. Ann Rheum Dis. 2018. PMID: 29102958 No abstract available.
Response to: 'Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases' by Visser et al.
Vergroesen RD, Slot LM, Hafkenscheid L, Koning MT, Scherer HU, Toes REM. Vergroesen RD, et al. Ann Rheum Dis. 2018 Oct;77(10):e70. doi: 10.1136/annrheumdis-2017-212583. Epub 2017 Nov 23. Ann Rheum Dis. 2018. PMID: 29170200 No abstract available.