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. 2017 Apr;15(4):231-238.
doi: 10.29252/ijrm.15.4.231.

Pregnancy outcome of "delayed start" GnRH antagonist protocol versus GnRH antagonist protocol in poor responders: A clinical trial study

Abbas Aflatoonian  1 , Aflatoonian Hosseinisadat  2 , Ramesh Baradaran  1 , Maryam Farid Mojtahedi  3
Affiliations

Pregnancy outcome of "delayed start" GnRH antagonist protocol versus GnRH antagonist protocol in poor responders: A clinical trial study

Abbas Aflatoonian et al. Int J Reprod Biomed. 2017 Apr.

Erratum in

Abstract

Background: Management of poor-responding patients is still major challenge in assisted reproductive techniques (ART). Delayed-start GnRH antagonist protocol is recommended to these patients, but little is known in this regards.

Objective: The goal of this study was assessment of delayed-start GnRH antagonist protocol in poor responders, and in vitro fertilization (IVF) outcomes.

Materials and methods: This randomized clinical trial included sixty infertile women with Bologna criteria for ovarian poor responders who were candidate for IVF. In case group (n=30), delayed-start GnRH antagonist protocol administered estrogen priming followed by early follicular-phase GnRH antagonist treatment for 7 days before ovarian stimulation with gonadotropin. Control group (n=30) treated with estrogen priming antagonist protocol. Finally, endometrial thickness, the rates of oocytes maturation, , embryo formation, and pregnancy were compared between two groups.

Results: Rates of implantation, chemical, clinical, and ongoing pregnancy in delayed-start cycles were higher although was not statistically significant. Endometrial thickness was significantly higher in case group. There were no statistically significant differences in the rates of oocyte maturation, embryo formation, and IVF outcomes between two groups.

Conclusion: There is no significant difference between delayed-start GnRH antagonist protocol versus GnRH antagonist protocol.

Keywords: GnRH antagonist protocol; In vitro fertilization; Poor responder; Pregnancy outcome.

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Conflict of interest statement

The authors declare they have no conflict of interest.

Figures

Figure 1
Figure 1
Consort flow diagram
See this image and copyright information in PMC

References

    1. Davar R, Rahsepar M, Rahmani E. A comparative study of luteal estradiol pre-treatment in GnRH antagonist protocols and in micro dose flare protocols for poor-responding patients. Arch Gynecol Obstet. 2013;287:149–153. - PubMed
    1. Tarlatzis BC, Zepiridis L, Grimbizis G, Bontis J. Clinical management of low ovarian response to stimulation for IVF: a systematic review. Hum Reprod Update. 2003;9:61–76. - PubMed
    1. Garcia J, Jones GS, Acosta AA, Wright Jr GL. Corpus luteum function after follicle aspiration for oocyte retrieval. Fertil Steril. 1981;36:565–572. - PubMed
    1. Kahraman K, Berker B, Atabekoglu CS, Sonmezer M, Cetinkaya E, Aytac R, Satiroglu H. Microdose gonadotropin-releasing hormone agonist flare-up protocol versus multiple dose gonadotropin-releasing hormone antagonist protocol in poor responders undergoing intracytoplasmic sperm injection-embryo transfer cycle. Fertil Steril. 2009;91:2437–2444. - PubMed
    1. Keay SD. Poor ovarian response to gonadotrophin stimulation-The role of adjuvant treatments. Hum Fertil. 2002;5 (Suppl.):S46–52. - PubMed

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