Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jan;43(1):162-165.
doi: 10.1007/s11064-017-2380-z. Epub 2017 Aug 24.

The Future Vocation of Neural Stem Cells: Lineage Commitment in Brain Development and Evolution

Tadashi Nomura  1 , Hitoshi Gotoh  2 , Katsuhiko Ono  2
Affiliations
Review

The Future Vocation of Neural Stem Cells: Lineage Commitment in Brain Development and Evolution

Tadashi Nomura et al. Neurochem Res. 2018 Jan.

Abstract

Understanding the fate commitment of neural stem cells is critical to identify the regulatory mechanisms in developing brains. Genetic lineage-tracing has provided a powerful strategy to unveil the heterogeneous nature of stem cells and their descendants. However, recent studies have reported controversial data regarding the heterogeneity of neural stem cells in the developing mouse neocortex, which prevents a decisive conclusion on this issue. Here, we review the progress that has been made using lineage-tracing analyses of the developing neocortex and discuss stem cell heterogeneity from the viewpoint of comparative and evolutionary biology.

Keywords: Evolution; Lineage commitment; Neocortex; Neural stem cells.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Nat Commun. 2013;4:2206 - PubMed
    1. Neuron. 1995 Aug;15(2):311-21 - PubMed
    1. Neural Dev. 2010 Mar 19;5:8 - PubMed
    1. Neuron. 2013 Dec 4;80(5):1167-74 - PubMed
    1. Neuron. 1995 Aug;15(2):299-310 - PubMed

LinkOut - more resources