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. 2017 Aug 24;16(1):162.
doi: 10.1186/s12944-017-0545-z.

Fractional esterification rate of cholesterol in high-density lipoprotein associates with risk of coronary heart disease

Junmeng Liu  1 , Ruiyue Yang  2 , Min Zhou  1 , Wen Mao  1 , Hongxia Li  2 , Haijian Zhao  3 , Shu Wang  2 , Wenxiang Chen  2   3 , Jun Dong  4 , Qing He  5
Affiliations

Fractional esterification rate of cholesterol in high-density lipoprotein associates with risk of coronary heart disease

Junmeng Liu et al. Lipids Health Dis. .

Abstract

Background: Fractional esterification rate of cholesterol in high-density lipoprotein (FERHDL) has been found to be closely correlated with atherosclerotic dyslipidemia, especially lipoprotein distributions, and is a potentially useful predictor for coronary heart disease (CHD). The associations of FERHDL, measured by the simple and precise HPLC method, with angiographically defined CHD and its related risk factors in Chinese patients were evaluated.

Methods: Two hundred and fifty eight Chinese patients who had indications for angiography were enrolled in this study. Coronary angiograms were obtained by the standard techniques. FERHDL was determined by the HPLC method. Cholesterol levels in serum HDL, LDL and subfractions were measured by ultracentrifugation/HPLC method. Associations between FERHDL and CHD and CHD risk factors were analyzed.

Results: FERHDL was correlated with almost all the CHD risk factors. Compared with the non-CHD group, the CHD patients had higher values of FERHDL (20.9 ± 7.9%/h vs 17.7 ± 7.1%/h, p = 0.001). FERHDL was found to be independently and positively correlated with log TG (β = 0.386, P < 0.001) and log (LDLb-C) (β = 0.165, P = 0.020), respectively, and negatively correlated with log (HDL2-C)(β = -0.351, P < 0.001). Logistic regression analysis demonstrated that age, diabetes mellitus, smoking and FERHDL (OR = 1.056-1.080, p < 0.05) were independent risk factors for CHD.

Conclusion: FERHDL significantly correlated with both HDL2-C and LDLb-C, and therefore, is the predictor of lipoprotein distributions. In addition, after correcting for the presence of classic risk factors, FERHDL was independently associated with the presence of angiographically defined CHD.

Keywords: Cholesterol; Coronary heart disease; Esterification rate; High density lipoprotein; Lipoprotein subfractions.

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Conflict of interest statement

Authors’ information

Not applicable.

Ethics approval and consent to participate

This study was reviewed and approved by the Beijing Hospital Ethics Committee. All studied individuals were informed in writing of the intended use of their samples and each provided written consent.

Consent for publication

Not applicable.

Competing interests

No authors declared any potential conflicts of interest. The funding organizations played no role in the design of the study, review and interpretation of data, or preparation or approval of the manuscript.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Serum FERHDL levels and severity of CHD. The 158 CHD patients were divided into 1-vessle (n = 51), 2-vessel (n = 44) and 3-vessel (n = 63) stenosed subgroups. The box plots show the median and 25th and 75th percentiles. Whiskers in the plots represent the highest and lowest values
See this image and copyright information in PMC

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