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. 2017 Sep 1;21(3):247-250.
doi: 10.5935/1518-0557.20170046.

Estradiol use in the luteal phase and its effects on pregnancy rates in IVF cycles with GnRH antagonist: a systematic review

Lanna Marla Andrade Pinheiro  1 , Priscilla da Silva Cândido  1 , Tássia Camila Moreto  1 , Wanessa Gonzaga Di Almeida  1 , Eduardo Camelo de Castro  1
Affiliations

Estradiol use in the luteal phase and its effects on pregnancy rates in IVF cycles with GnRH antagonist: a systematic review

Lanna Marla Andrade Pinheiro et al. JBRA Assist Reprod. .

Abstract

For all the steps of in vitro fertilization to occur successfully, factors such as the quality of retrieved oocytes and endometrial receptivity to the embryo must be ensured. Current studies have shown that endometrial receptivity can be optimized using dedicated exogenous progesterone for luteal phase support in assisted reproduction cycles. But it has not yet been established the benefits of additional use of estradiol in this support. Analyzing pituitary suppression protocols that employ GnRH antagonists, this review will address literature publications between the years 2000-2016, shedding light on this issue to answer questions about the benefits of supplementation.

Keywords: estradiol; in vitro fertilization.; luteal phase.

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Figure 1.
Methodology used in the systematic review construction.
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References

    1. Aboulghar M. Luteal support in reproduction: when, what and how? Curr Opin Obstet Gynecol. 2009;21:279–284. doi: 10.1097/GCO.0b013e32832952ab. - DOI - PubMed
    1. Ceyhan ST, Basaran M, Kemal Duru N, Yilmaz A, Göktolga U, Baser I. Use of luteal estrogen supplementation in normal responder patients treated with fixed multidose GnRH antagonist: a prospective randomized controlled study. Fertil Steril. 2008;89:1827–1830. doi: 10.1016/j.fertnstert.2007.08.029. - DOI - PubMed
    1. Fatemi HM, Kolibianakis EM, Camus M, Tournaye H, Donoso P, Papanikolaou E, Devroey P. Addition of estradiol to progesterone for luteal supplementation in patients stimulated with GnRH antagonist/rFSH for IVF: a randomized controlled trial. Hum Reprod. 2006;21:2628–2632. doi: 10.1093/humrep/del117. - DOI - PubMed
    1. Huang N, Situ B, Chen X, Liu J, Yan P, Kang X, Kong S, Huang M. Meta-analysis of estradiol for luteal phase support in in vitro fertilization/intracytoplasmic sperm injection. Fertil Steril. 2015;103:367–373.e5. doi: 10.1016/j.fertnstert.2014.10.029. - DOI - PubMed
    1. Kwon SK, Kim CH, Lee KH, Jeon IK, Ahn JW, Kim SH, Chae HD, Kang BM. Luteal estradiol supplementation in gonadotropin-releasing hormone antagonist cycles for infertile patients in vitro fertilization. Clin Exp Reprod Med. 2013;40:131–134. doi: 10.5653/cerm.2013.40.3.131. - DOI - PMC - PubMed

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