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Review
. 2018 May-Jun;63(3):381-388.
doi: 10.1016/j.survophthal.2017.08.005. Epub 2017 Aug 31.

Ocular/adnexal lymphoma: dissimilar to systemic lymphoma

Tal J Rubinstein  1 , Hassan A Aziz  2 , Claudine Bellerive  2 , Bryan S Sires  1 , Andrew W Hing  3 , Gabriel Habermehl  4 , Eric Hsi  4 , Arun D Singh  5
Affiliations
Review

Ocular/adnexal lymphoma: dissimilar to systemic lymphoma

Tal J Rubinstein et al. Surv Ophthalmol. 2018 May-Jun.

Abstract

Ocular adnexal lymphoma and intraocular lymphoma, whether occurring simultaneously or sequentially, are often similar to associated systemic lymphoma. We describe 4 cases of ocular adnexal lymphoma or intraocular lymphoma with a dissimilar systemic lymphoma. Two of the cases represent Richter transformation of chronic lymphocytic leukemia/small-cell lymphoma into diffuse large B-cell lymphoma. In the third patient, conjunctival extranodal marginal zone lymphoma developed following treatment for Hodgkin lymphoma. The fourth patient had a remote history of systemic diffuse large B-cell lymphoma with a subsequent diagnosis of orbital extranodal marginal zone lymphoma. Clinical-pathological correlation is reported for all cases in addition to pertinent review of the literature.

Keywords: chronic lymphocytic leukemia; diffuse large B-cell lymphoma; extranodal marginal zone lymphoma; intraocular lymphoma; non-Hodgkin's lymphoma; ocular adnexal lymphoma; small cell lymphoma.

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