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Case Reports
. 2017 Sep:111:65-68.
doi: 10.1016/j.lungcan.2017.07.012. Epub 2017 Jul 11.

Lack of response to nivolumab in a patient with EGFR-mutant non-small cell lung cancer adenocarcinoma sub-type transformed to small cell lung cancer

Nadza Tokaca  1 , Andrew Wotherspoon  2 , Andrew G Nicholson  3 , Nicos Fotiadis  4 , Lisa Thompson  5 , Sanjay Popat  6
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Free article
Case Reports

Lack of response to nivolumab in a patient with EGFR-mutant non-small cell lung cancer adenocarcinoma sub-type transformed to small cell lung cancer

Nadza Tokaca et al. Lung Cancer. 2017 Sep.
Free article

Abstract

Small cell transformation is a rare but well recognised mechanism of acquired resistance to EGFR-TKI therapy in EGFR-mutated NSCLC, but optimal drug therapy thereof is unknown. Nivolumab has demonstrated activity in relapsed de novo small cell lung cancer in early phase trials. Here, we report a case of transformed EGFR-mutant SCLC treated with nivolumab with no benefit.

Keywords: Adenocarcinoma; EGFR; NSCLC; Nivolumab; Small cell lung cancer; Transformation.

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