Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017:150:455-485.
doi: 10.1016/bs.pmbts.2017.06.017. Epub 2017 Aug 2.

Biosafety of Prions

Edoardo Bistaffa  1 , Martina Rossi  2 , Chiara M G De Luca  3 , Fabio Moda  4
Affiliations
Review

Biosafety of Prions

Edoardo Bistaffa et al. Prog Mol Biol Transl Sci. 2017.

Abstract

Prions are the infectious agents that cause devastating and untreatable disorders known as Transmissible Spongiform Encephalopathies (TSEs). The pathologic events and the infectious nature of these transmissible agents are not completely understood yet. Due to the difficulties in inactivating prions, working with them requires specific recommendations and precautions. Moreover, with the advent of innovative technologies, such as the Protein Misfolding Cyclic Amplification (PMCA) and the Real Time Quaking-Induced Conversion (RT-QuIC), prions could be amplified in vitro and the infectious features of the amplified products need to be carefully assessed.

Keywords: Biosafety; Decontamination; Infectivity; Prion diseases; Transmission.

PubMed Disclaimer

LinkOut - more resources