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. 1987 May;40(5):453-63.

Polynesian origins and affinities: globin gene variants in eastern Polynesia

A V Hill, B Gentile, J M Bonnardot, J Roux, D J Weatherall, J B Clegg

Polynesian origins and affinities: globin gene variants in eastern Polynesia

A V Hill et al. Am J Hum Genet. 1987 May.

Abstract

Analysis of copy number variants of the duplicated alpha-, zeta-, and gamma-globin genes in eastern Polynesians revealed a high frequency of both triplicated-zeta-gene chromosomes and a specific alpha thalassemia deletion. This deletion and a novel restriction-enzyme-site polymorphism associated with a zeta zeta zeta chromosome are found only in Melanesians and Polynesians. Analysis of alpha-globin restriction-enzyme haplotypes indicated further similarities to Melanesians but suggested an additional non-Melanesian genetic component in eastern Polynesia. Several globin gene alleles showed evidence of marked frequency fluctuations due to genetic drift.

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