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Meta-Analysis
. 2017:2017:6136205.
doi: 10.1155/2017/6136205. Epub 2017 Aug 3.

Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis

Shibing Xu  1   2   3 , Lei Zhang  1   2   3 , Hongting Jin  2   3 , Letian Shan  2   3 , Li Zhou  2   3 , Luwei Xiao  2   3 , Peijian Tong  2   3   4
Affiliations
Meta-Analysis

Autologous Stem Cells Combined Core Decompression for Treatment of Avascular Necrosis of the Femoral Head: A Systematic Meta-Analysis

Shibing Xu et al. Biomed Res Int. 2017.

Abstract

Objective: This study aims to systematically evaluate the efficacy and safety of core decompression combined transplantation of autologous bone marrow stem cells (CDBMSCs) for treatment of avascular necrosis of the femoral head (ANFH).

Methods: Randomized controlled trials (RCTs) regarding effectiveness of core decompression combined transplantation of autologous bone marrow stem cells for treating ANFH were searched in 8 comprehensive databases prior to September 2016. The data analysis was performed by using the RevMan version 5.3.

Results: A total of 11 studies with 507 participants were included. Results showed that CDBMSCs group was more effective than CD group in increasing Harris hip score, decreasing necrotic area of femoral head, collapse of femoral head, and conversion to total hip replacement incidence. In the subgroup analysis, the results did not change in different intervention measure substantially. In addition, the safety of CDBMSCs for ANFH is reliable.

Conclusion: Based on the systematic review, our findings suggest that core decompression combined transplantation of autologous bone marrow stem cells appeared to be more efficacious in the treatment at early stages of ANFH.

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Figures

Figure 1
Figure 1
Flow diagram of the study selection procedure.
Figure 2
Figure 2
Quality assessment of included studies. Risk of bias graph.
Figure 3
Figure 3
Forest plot of experimental treatment versus control group interventions on Harris hip scores according to intervention measure.
Figure 4
Figure 4
Forest plot of experimental treatment versus control group interventions on postoperation necrotic area according to intervention measure.
Figure 5
Figure 5
Forest plot of experimental treatment versus control group interventions on collapse of femoral head.
Figure 6
Figure 6
Forest plot of experimental treatment versus control group interventions on THA of femoral head.
See this image and copyright information in PMC

References

    1. Jones K. B., Seshadri T., Krantz R., Keating A., Ferguson P. C. Cell-based therapies for osteonecrosis of the femoral head. Biology of Blood and Marrow Transplantation. 2008;14(10):1081–1087. doi: 10.1016/j.bbmt.2008.06.017. - DOI - PubMed
    1. Marker D. R., Seyler T. M., Ulrich S. D., Srivastava S., Mont M. A. Do modern techniques improve core decompression outcomes for hip osteonecrosis? Clinical Orthopaedics and Related Research. 2008;466(5):1093–1103. doi: 10.1007/s11999-008-0184-9. - DOI - PMC - PubMed
    1. Mont M. A., Hungerford D. S. Non-traumatic avascular necrosis of the femoral head. Journal of Bone and Joint Surgery A. 1995;77(3):459–474. doi: 10.2106/00004623-199503000-00018. - DOI - PubMed
    1. Lieberman J. R., Berry D. J., Mont M. A., et al. Osteonecrosis of the hip: management in the 21st century. Instructional Course Lectures. 2003;52:337–355. - PubMed
    1. Cardozo J. B., Andrade D. M. S., Santiago M. B. The use of bisphosphonate in the treatment of avascular necrosis: a systematic review. Clinical Rheumatology. 2008;27(6):685–688. doi: 10.1007/s10067-008-0861-9. - DOI - PubMed

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