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. 1987 Jun 5;49(5):633-42.
doi: 10.1016/0092-8674(87)90539-3.

A histidine-rich protein gene marks a linkage group favored strongly in a genetic cross of Plasmodium falciparum

T E Wellems, D Walliker, C L Smith, V E do Rosario, W L Maloy, R J Howard, R Carter, T F McCutchan

A histidine-rich protein gene marks a linkage group favored strongly in a genetic cross of Plasmodium falciparum

T E Wellems et al. Cell. .

Abstract

Two histidine-rich protein genes in Plasmodium falciparum are related by an ancestral duplication and interchromosomal transposition. We have followed the inheritance of these genes in a cross between two clones of P. falciparum. Examination of progeny shows that one gene, encoding the protein HRP-II, behaves as expected and may be inherited from either parent. The other gene, encoding HRP-III, has been found to derive from one parent in all progeny examined. We conclude the linkage group marked by HRP-III is favored strongly in the cross. This linkage group spans a region at one end of chromosome 13. Growth studies suggest the favored inheritance is explained by rapid expansion of progeny possessing the HRP-III marker relative to slower growth of progeny without it.

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