A histidine-rich protein gene marks a linkage group favored strongly in a genetic cross of Plasmodium falciparum
- PMID: 2884039
- DOI: 10.1016/0092-8674(87)90539-3
A histidine-rich protein gene marks a linkage group favored strongly in a genetic cross of Plasmodium falciparum
Abstract
Two histidine-rich protein genes in Plasmodium falciparum are related by an ancestral duplication and interchromosomal transposition. We have followed the inheritance of these genes in a cross between two clones of P. falciparum. Examination of progeny shows that one gene, encoding the protein HRP-II, behaves as expected and may be inherited from either parent. The other gene, encoding HRP-III, has been found to derive from one parent in all progeny examined. We conclude the linkage group marked by HRP-III is favored strongly in the cross. This linkage group spans a region at one end of chromosome 13. Growth studies suggest the favored inheritance is explained by rapid expansion of progeny possessing the HRP-III marker relative to slower growth of progeny without it.
Similar articles
-
An RFLP map of the Plasmodium falciparum genome, recombination rates and favored linkage groups in a genetic cross.Mol Biochem Parasitol. 1992 Apr;51(2):313-20. doi: 10.1016/0166-6851(92)90081-t. Mol Biochem Parasitol. 1992. PMID: 1349423
-
Histidine-rich protein genes and their transcripts in Plasmodium falciparum and P. lophurae.Mol Biochem Parasitol. 1984 May;12(1):85-94. doi: 10.1016/0166-6851(84)90046-x. Mol Biochem Parasitol. 1984. PMID: 6205271
-
Molecular karyotype of Plasmodium falciparum: conserved linkage groups and expendable histidine-rich protein genes.Proc Natl Acad Sci U S A. 1987 Nov;84(21):7672-6. doi: 10.1073/pnas.84.21.7672. Proc Natl Acad Sci U S A. 1987. PMID: 3313401 Free PMC article.
-
Genomic organization, structure and possible function of histidine-rich proteins of malaria parasites.Int J Biochem. 1988;20(5):471-7. doi: 10.1016/0020-711x(88)90495-8. Int J Biochem. 1988. PMID: 3286310 Review.
-
Analysis of malaria parasite phenotypes using experimental genetic crosses of Plasmodium falciparum.Int J Parasitol. 2012 May 15;42(6):529-34. doi: 10.1016/j.ijpara.2012.03.004. Epub 2012 Mar 29. Int J Parasitol. 2012. PMID: 22475816 Free PMC article. Review.
Cited by
-
Plasmodium falciparum purine nucleoside phosphorylase is critical for viability of malaria parasites.J Biol Chem. 2008 Dec 19;283(51):35899-907. doi: 10.1074/jbc.M807218200. Epub 2008 Oct 28. J Biol Chem. 2008. PMID: 18957439 Free PMC article.
-
Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil.Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6. doi: 10.1073/pnas.94.20.10931. Proc Natl Acad Sci U S A. 1997. PMID: 9380737 Free PMC article.
-
Karyotype analysis of virulent Plasmodium falciparum strains propagated in Saimiri sciureus: strain adaptation leads to deletion of the RESA gene.Infect Immun. 1995 Feb;63(2):693-5. doi: 10.1128/iai.63.2.693-695.1995. Infect Immun. 1995. PMID: 7822042 Free PMC article.
-
Telomeric location of Giardia rDNA genes.Mol Cell Biol. 1991 Jun;11(6):3326-30. doi: 10.1128/mcb.11.6.3326-3330.1991. Mol Cell Biol. 1991. PMID: 2038335 Free PMC article.
-
Organization of subtelomeric repeats in Plasmodium berghei.Mol Cell Biol. 1990 May;10(5):2423-7. doi: 10.1128/mcb.10.5.2423-2427.1990. Mol Cell Biol. 1990. PMID: 2183034 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
