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Review
. 2017 Aug 25;18(9):1850.
doi: 10.3390/ijms18091850.

Importance of Endogenous Fibrinolysis in Platelet Thrombus Formation

Ying X Gue  1 , Diana A Gorog  2   3   4
Affiliations
Review

Importance of Endogenous Fibrinolysis in Platelet Thrombus Formation

Ying X Gue et al. Int J Mol Sci. .

Abstract

The processes of thrombosis and coagulation are finely regulated by endogenous fibrinolysis maintaining healthy equilibrium. When the balance is altered in favour of platelet activation and/or coagulation, or if endogenous fibrinolysis becomes less efficient, pathological thrombosis can occur. Arterial thrombosis remains a major cause of morbidity and mortality in the world despite advances in medical therapies. The role endogenous fibrinolysis in the pathogenesis of arterial thrombosis has gained increasing attention in recent years as it presents novel ways to prevent and treat existing diseases. In this review article, we discuss the role of endogenous fibrinolysis in platelet thrombus formation, methods of measurement of fibrinolytic activity, its role in predicting cardiovascular diseases and clinical outcomes and future directions.

Keywords: cardiovascular; endogenous; fibrinolysis; platelets; spontaneous; thrombolysis; thrombosis.

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Conflict of interest statement

Diana A Gorog is related by family to a company director in Thromboquest Ltd., but has no financial involvement or equity interest in, and has received no financial assistance, support or grant from the aforementioned company. There are no other contracts, benefits or personal relationships to disclose.

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