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Comment
. 2017 Aug 24;170(5):823-825.
doi: 10.1016/j.cell.2017.08.010.

Reprogramming Enhancers to Drive Metastasis

Raul Mostoslavsky  1 , Nabeel Bardeesy  2
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Free article
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Reprogramming Enhancers to Drive Metastasis

Raul Mostoslavsky et al. Cell. .
Free article

Abstract

Acquired molecular changes can promote the spreading of primary tumor cells to distant tissues. In this issue of Cell, Roe et al. show that metastatic progression of pancreatic cancer involves large-scale enhancer reprogramming by Foxa1, which activates transcriptional program specifying early endodermal stem cells.

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  • Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis.
    Roe JS, Hwang CI, Somerville TDD, Milazzo JP, Lee EJ, Da Silva B, Maiorino L, Tiriac H, Young CM, Miyabayashi K, Filippini D, Creighton B, Burkhart RA, Buscaglia JM, Kim EJ, Grem JL, Lazenby AJ, Grunkemeyer JA, Hollingsworth MA, Grandgenett PM, Egeblad M, Park Y, Tuveson DA, Vakoc CR. Roe JS, et al. Cell. 2017 Aug 24;170(5):875-888.e20. doi: 10.1016/j.cell.2017.07.007. Epub 2017 Jul 27. Cell. 2017. PMID: 28757253 Free PMC article.

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