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. 2017 Dec 1:175:347-351.
doi: 10.1016/j.talanta.2017.07.023. Epub 2017 Jul 11.

A novel label-free electrochemical immunosensor based on aldehyde-terminated ionic liquid

Youming Shen  1 , Guangyu Shen  2 , Youyu Zhang  3 , Chunxiang Zhang  4 , Haitao Li  3
Affiliations

A novel label-free electrochemical immunosensor based on aldehyde-terminated ionic liquid

Youming Shen et al. Talanta. .

Abstract

In this paper, aldehyde-terminated ionic liquid was synthesized and used to fabricate a novel label-free electrochemical immunosensor for the determination of hepatitis B surface antigen. This sensor was formed from a gold electrode which was modified with a composite film containing the aldehyde-functionalized ionic liquid incorporated into nafion and anti-hepatitis B surface antigen antibody probes. Aldehyde-functionalized ionic liquid was used not only as a substrate for antibody immobilization, but also as a good material with high electrical conductivity, which greatly simplified the process of sensor fabrication. The proposed sensor exhibited a good performance in a linear range from 0.05 to 15ngmL-1 with a detection limit of 20pgmL-1 (S/N=3) and provided a novel strategy for clinical detection due to satisfying stability, selectivity and reproducibility.

Keywords: Aldehyde-terminated ionic liquid; Antibody immobilization; Electrochemical immunosensor; Hepatitis B surface antigen.

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