doi: 10.1111/j.2042-7158.1987.tb06280.x.
Potentiation of contractile response and increase in tissue sodium content induced by aconitine in the guinea-pig vas deferens
- PMID: 2884304
- DOI: 10.1111/j.2042-7158.1987.tb06280.x
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Potentiation of contractile response and increase in tissue sodium content induced by aconitine in the guinea-pig vas deferens
J Pharm Pharmacol.
1987 Apr.
Abstract
Aconitine potentiated the contractile response of the guinea-pig vas deferens and increased the tissue Na and Ca content. These effects were abolished in the presence of tetrodotoxin. These results suggest that aconitine causes an increasing Na+ permeability of the smooth muscle membrane to increase Ca2+ availability and thus induces potentiation.
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