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Review
. 2017 Sep;137(9):1826-1828.
doi: 10.1016/j.jid.2017.06.014.

Langerhans Cells Orchestrate TFH-Dependent Humoral Immunity

Trupti Vardam  1 , Niroshana Anandasabapathy  2
Affiliations
Review

Langerhans Cells Orchestrate TFH-Dependent Humoral Immunity

Trupti Vardam et al. J Invest Dermatol. 2017 Sep.

Abstract

T follicular helper cells contribute to the development of long-lasting humoral immunity by germinal center formation. Somatic hypermutation and affinity maturation take place in germinal centers leading to the generation of memory B cells and plasma cells. As such, T follicular helper cells impact immunodeficiencies, autoimmunity, and cancer. This necessitates further understanding of how T follicular helper cells are regulated in health and disease. The current study by Levin et al. builds on prior work to further substantiate a critical role for skin migratory dendritic cells and in particular Langerhans cells at governing T follicular helper and germinal center formation after intradermal immunization with HIV p24-coated polylactic acid nanoparticles.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors state no conflict of interest.

Figures

Figure 1.
Figure 1.
Intradermal immunization activates epidermal Langerhans cells that present antigen to naïve CD4+ T cells in the draining lymph node leading to TFH differentiation. TFH cells are critical for generation and maintenance of germinal centers (GCs). TFH, T follicular helper.
See this image and copyright information in PMC

Comment on

References

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