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. 1987 Jul;61(7):2339-43.
doi: 10.1128/JVI.61.7.2339-2343.1987.

Insertion and truncation of c-myb by murine leukemia virus in a myeloid cell line derived from cultures of normal hematopoietic cells

Y Weinstein, J L Cleveland, D S Askew, U R Rapp, J N Ihle

Insertion and truncation of c-myb by murine leukemia virus in a myeloid cell line derived from cultures of normal hematopoietic cells

Y Weinstein et al. J Virol. 1987 Jul.

Abstract

A retroviral insertion into the c-myb gene, which resulted in a 3' truncation, was found in an in vitro-derived myeloid cell line. The retroviral insertion occurred at precisely the same nucleotide at which another murine leukemia virus insertion occurred in an in vivo-induced myeloid leukemia. These findings suggest that comparable events may be required for the derivation of myeloid cell lines in vitro and for induction of myeloid leukemia in vivo.

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References

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