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Review
. 2017 Oct 18;63(5):439-443.
doi: 10.1262/jrd.2016-093. Epub 2017 Aug 28.

Is transcription in sperm stationary or dynamic?

Xiaoxia Ren  1 , Xiaoli Chen  1 , Zhenling Wang  2 , Dong Wang  1
Affiliations
Review

Is transcription in sperm stationary or dynamic?

Xiaoxia Ren et al. J Reprod Dev. .

Abstract

Transcriptional activity is repressed due to the packaging of sperm chromatins during spermiogenesis. The detection of numerous transcripts in sperm, however, raises the question whether transcriptional events exist in sperm, which has been the central focus of the recent studies. To summarize the transcriptional activity during spermiogenesis and in sperm, we reviewed the documents on transcript differences during spermiogenesis, in sperm with differential motility, before and after capacitation and cryopreservation. This will lay a theoretical foundation for studying the mechanism(s) of gene expression in sperm, and would be invaluable in making better use of animal sires and developing reproductive control technologies.

Keywords: Cryopreservation; Spermatozoa; Spermiogenesis; Transcriptional activity.

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References

    1. Rathke C, Baarends WM, Awe S, Renkawitz-Pohl R. Chromatin dynamics during spermiogenesis. Biochim Biophys Acta 2014; 1839: 155–168. - PubMed
    1. Gaucher J, Reynoird N, Montellier E, Boussouar F, Rousseaux S, Khochbin S. From meiosis to postmeiotic events: the secrets of histone disappearance. FEBS J 2010; 277: 599–604. - PubMed
    1. Gaucher J, Boussouar F, Montellier E, Curtet S, Buchou T, Bertrand S, Hery P, Jounier S, Depaux A, Vitte AL, Guardiola P, Pernet K, Debernardi A, Lopez F, Holota H, Imbert J, Wolgemuth DJ, Gérard M, Rousseaux S, Khochbin S. Bromodomain-dependent stage-specific male genome programming by Brdt. EMBO J 2012; 31: 3809–3820. - PMC - PubMed
    1. Goudarzi A, Shiota H, Rousseaux S, Khochbin S. Genome-scale acetylation-dependent histone eviction during spermatogenesis. J Mol Biol 2014; 426: 3342–3349. - PubMed
    1. Yang Z, Gallicano GI, Yu QC, Fuchs E. An unexpected localization of basonuclin in the centrosome, mitochondria, and acrosome of developing spermatids. J Cell Biol 1997; 137: 657–669. - PMC - PubMed