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. 2017 Aug;47(4):198-204.
doi: 10.4274/tjo.87300. Epub 2017 Aug 15.

Selective Laser Trabeculoplasty vs. Fixed Combinations with Timolol in Practice: A Replacement Study in Primary Open Angle Glaucoma

Ali Kutlay Tufan  1 , İsmail Umut Onur  1 , Fadime Ulviye Yiğit  1 , Ahmet Ağaçhan  1 , Şenay Aşık Nacaroğlu  1
Affiliations

Selective Laser Trabeculoplasty vs. Fixed Combinations with Timolol in Practice: A Replacement Study in Primary Open Angle Glaucoma

Ali Kutlay Tufan et al. Turk J Ophthalmol. 2017 Aug.

Abstract

Objectives: To evaluate the potential of selective laser trabeculoplasty (SLT) in two arms (360˚ vs. 180˚) as a replacement for fixed combinations (FCs) with timolol in primary open angle glaucoma over 6 months.

Materials and methods: Of 40 patients in a prospective, comparative, interventional case series, 18 eyes and 22 eyes were randomized to SLT 180º and SLT 360º groups, respectively, along with 40 fellow-control eyes. FC with timolol was discontinued on the day of treatment for the eye to be operated on, while ongoing therapy was not interrupted for the contralateral eye. Eyes were examined for intraocular pressure (IOP) elevation 1 hour and 1 day after SLT. The follow-up visits were then scheduled for 1 week, 1 month, 3 months, and 6 months after, during the which the IOP of both eyes and any possible complications were evaluated.

Results: There were no statistically significant differences in mean IOPs through 6 months among the groups with exception of postlaser 1 hour and postlaser 1 day (p<0.001 and p=0.010, respectively). Multiple comparison analysis showed significantly higher IOP in both SLT 180º and SLT 360º subgroups compared to their controls at postlaser 1 hour (p=0.007, p<0.001) but significantly lower IOP only in SLT 360º subgroup compared to the controls at postlaser day 1 (p=0.013).

Conclusion: SLT offers promising potential as a substitute equivalent to efficacy of FCs with timolol. However, SLT 360˚ may not achieve additional IOP reduction.

Keywords: Fixed combination antiglaucoma medications; intraocular pressure reduction rate; primary open-angle glaucoma; selective laser trabeculoplasty.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1. Course of mean intraocular pressures through six months SLT: Selective laser trabeculoplasty, IOP: Intraocular pressure
See this image and copyright information in PMC

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