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. 1987 May 25;40(21):2067-76.
doi: 10.1016/0024-3205(87)90099-3.

Identification of dynorphin 1-8 in human placenta by mass spectrometry

M S Ahmed, L W Randall, B Sibai, C Dass, G Fridland, D M Desiderio, E Tolun

Identification of dynorphin 1-8 in human placenta by mass spectrometry

M S Ahmed et al. Life Sci. .

Abstract

The human placental villus tissue contains opioid receptors and peptides. The opioid peptides extracted from the villus tissue were fractionated using reverse-phase high performance liquid chromatography and a radio-receptor assay. The presence of dynorphin 1-8 was corroborated by mass spectrometric production of (M + H) ion in the fast atom bombardment mode. This octa-peptide could be the natural ligand of the kappa opioid receptors present in the human placental villus tissue.

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