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. 2017 Aug 28;12(8):e0182769.
doi: 10.1371/journal.pone.0182769. eCollection 2017.

Association between mitochondrial DNA variations and schizophrenia in the northern Chinese Han population

Feng-Ling Xu  1 , Mei Ding  1 , Jun Yao  1 , Zhang-Sen Shi  1 , Xue Wu  1 , Jing-Jing Zhang  1 , Hao Pang  1 , Jia-Xin Xing  1 , Jin-Feng Xuan  1 , Bao-Jie Wang  1
Affiliations

Association between mitochondrial DNA variations and schizophrenia in the northern Chinese Han population

Feng-Ling Xu et al. PLoS One. .

Abstract

To determine whether mitochondrial DNA (mtDNA) variations are associated with schizophrenia, 313 patients with schizophrenia and 326 unaffected participants of the northern Chinese Han population were included in a prospective study. Single-nucleotide polymorphisms (SNPs) including C5178A, A10398G, G13708A, and C13928G were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Hypervariable regions I and II (HVSI and HVSII) were analyzed by sequencing. The results showed that the 4 SNPs and 11 haplotypes, composed of the 4 SNPs, did not differ significantly between patient and control groups. No significant association between haplogroups and the risk of schizophrenia was ascertained after Bonferroni correction. Drawing a conclusion, there was no evidence of an association between mtDNA (the 4 SNPs and the control region) and schizophrenia in the northern Chinese Han population.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

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