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Randomized Controlled Trial
. 2017 Aug 8:12:1223-1231.
doi: 10.2147/CIA.S141518. eCollection 2017.

Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections: A randomized controlled open-label trial

Fangfang Pu  1 , Yue Guo  1   2 , Ming Li  1 , Hong Zhu  3 , Shijie Wang  3 , Xi Shen  1 , Miao He  1 , Chengyu Huang  1 , Fang He  1
Affiliations
Randomized Controlled Trial

Yogurt supplemented with probiotics can protect the healthy elderly from respiratory infections: A randomized controlled open-label trial

Fangfang Pu et al. Clin Interv Aging. .

Abstract

Purpose: To evaluate whether yogurt supplemented with a probiotic strain could protect middle-aged and elderly people from acute upper respiratory tract infections (URTI) using a randomized, blank-controlled, parallel-group design.

Patients and methods: Two hundred and five volunteers aged ≥45 years were randomly divided into two groups. The subjects in the intervention group were orally administered 300 mL/d of yogurt supplemented with a probiotic strain, Lactobacillus paracasei N1115 (N1115), 3.6×107 CFU/mL for 12 weeks, while those in the control group retained their normal diet without any probiotic supplementation. The primary outcome was the incidence of URTI, and changes in serum protein, immunoglobulins, and the profiles of the T-lymphocyte subsets (total T-cells [CD3+], T-helper cells [CD4+], and T-cytotoxic-suppressor cells [CD8+]) during the intervention were the secondary outcomes.

Results: Compared to the control group, the number of persons diagnosed with an acute URTI and the number of URTI events significantly decreased in the intervention group (P=0.038, P=0.030, respectively). The risk of URTI in the intervention group was evaluated as 55% of that in the control group (relative risk =0.55, 95% CI: 0.307-0.969). The change in the percentage of CD3+ cells in the intervention group was significantly higher than in the control group (P=0.038). However, no significant differences were observed in the total protein, albumin, globulin, and prealbumin levels in both groups (P>0.05).

Conclusion: The study suggested that yogurt with selected probiotic strains such as N1115 may reduce the risk of acute upper tract infections in the elderly. The enhancement of the T-cell-mediated natural immune defense might be one of the important underlying mechanisms for probiotics to express their anti-infective effects.

Keywords: Lactobacillus paracasei N1115; acute upper respiratory tract infection; elderly; immunosenescence; probiotics; yogurt.

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Conflict of interest statement

Disclosure This work was supported by Shijiazhuang Junlebao Dairy Co. Ltd. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Volunteer flow in the study. Note: Values are expressed as the number of participants.
Figure 2
Figure 2
Percentage of volunteers by URTI score for all URTI (A) and effect of the tested yogurt on severity of URTI (B) during the study phase. Notes: The y-axis represents the percentage of volunteers. The x-axis describes the URTI score. The percentage of URTI score higher than 7 in the intervention group was 0%, which in the control group was 3.8%. Abbreviation: URTI, upper respiratory tract infection.
Figure 3
Figure 3
Comparison change from baseline in the percentages of CD3+, CD4+, and CD8+ (A) and levels of IgA, IgG, and IgM (B) in the intervention group and the control group. Notes: Values are means for the participants, with standard deviations represented by vertical bars. *P<0.05 (t-test).
See this image and copyright information in PMC

References

    1. Girard MP, Cherian T, Pervikov Y, Kieny MP. A review of vaccine research and development: human acute respiratory infections. Vaccine. 2006;24(15):2732–2750. - PMC - PubMed
    1. Borchers AT, Selmi C, Meyers FJ, Keen CL, Gershwin ME. Probiotics and immunity. J Gastroenterol. 2009;44(1):26–46. - PubMed
    1. Bourlioux P, Pochart P. Nutritional and health properties of yogurt. World Rev Nutr Diet. 1988;56:217–258. - PubMed
    1. Nova E, Wärnberg J, Gómez-Martínez S, Díaz LE, Romeo J, Marcos A. Immunomodulatory effects of probiotics in different stages of life. Br J Nutr. 2007;98(Suppl 1):90–95. - PubMed
    1. Dong H, Rowland I, Thomas LV, Yaqoob P. Immunomodulatory effects of a probiotic drink containing Lactobacillus casei Shirota in healthy older volunteers. Eur J Nutr. 2013;52(8):1853–1863. - PubMed

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