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Review
. 2017 Mar 27;2(Suppl 1):e000152.
doi: 10.1136/esmoopen-2016-000152. eCollection 2017.

New molecular and immunotherapeutic approaches in biliary cancer

David Goldstein  1 , Charlotte Lemech  2 , Juan Valle  3
Affiliations
Review

New molecular and immunotherapeutic approaches in biliary cancer

David Goldstein et al. ESMO Open. .

Abstract

Biliary tract carcinoma is a collective term for a group of rare gastrointestinal cancers. This overview outlines the key pathways and specialised therapeutics in biliary cancer and the emerging role of immunotherapy by highlighting the rationale and selected examples of studies in each area.

Keywords: biliary cancer.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Molecular spectra of BTC. In addition to subtype-specific characteristics, alterations were identified that were common to ICCite targetable trahepatic cholangiocarcinoma and ECC or common to all three subtypes. Blue symbols indicae genes.1
See this image and copyright information in PMC

References

    1. GBD. Mortality and causes of death collaborators. global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the global burden of disease study 2013. Lancet 2013;2015:117–71. - PMC - PubMed
    1. Jain A, Javle M. Molecular profiling of biliary tract cancer: a target rich disease. J Gastrointest Oncol 2016;7:797–803.10.21037/jgo.2016.09.01 - DOI - PMC - PubMed
    1. Marcano-Bonilla L, Mohamed EA, Mounajjed T, et al. . Biliary tract cancers: epidemiology, molecular pathogenesis and genetic risk associations. Chin Clin Oncol 2016;5:61 no 510.21037/cco.2016.10.09 - DOI - PubMed
    1. Hezel AF, Deshpande V, Zhu AX. Genetics of biliary tract cancers and emerging targeted therapies. J Clin Oncol 2010;28:3531–40.10.1200/JCO.2009.27.4787 - DOI - PMC - PubMed
    1. Jordan E, Abou-Alfa GK, Lowery MA. Systemic therapy for biliary cancers. Chin Clin Oncol 2016;5:65 no 510.21037/cco.2016.10.08 - DOI - PubMed

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